非天然受体的工程设计。

Engineering of non-natural receptors.

作者信息

Mathonet Pascale, Fastrez Jacques

机构信息

Laboratoire de Biochimie Physique et des Biopolymères, Institut des Sciences de la Vie, place Louis Pasteur 1, B1348 Louvain-la-Neuve, Belgium.

出版信息

Curr Opin Struct Biol. 2004 Aug;14(4):505-11. doi: 10.1016/j.sbi.2004.06.007.

DOI:10.1016/j.sbi.2004.06.007

PMID:15313246

Abstract

Rational design, usually guided by computational prediction, and selection from libraries of variants of natural proteins have been used with success in the engineering of novel non-natural receptors. Many of these engineered protein binders will find use in biotechnological, diagnostic and medical applications, sometimes in the place of natural antibodies.

摘要

合理设计通常由计算预测引导，并从天然蛋白质变体库中进行筛选，已成功用于新型非天然受体的工程设计。许多这些工程化的蛋白质结合剂将用于生物技术、诊断和医学应用，有时可替代天然抗体。