Buitenhuis Miranda, Coffer Paul J, Koenderman Leo
Department of Pulmonary Diseases, G03.550, University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
Int J Biochem Cell Biol. 2004 Nov;36(11):2120-4. doi: 10.1016/j.biocel.2003.11.008.
Signal transducer and activator of transcription 5 (STAT5) activity is induced by a plethora of cytokines and growth factors resulting in transcriptional activation of specific target genes. STAT5 plays an important role in a variety of cellular processes, including proliferation, differentiation, and apoptosis. Aberrant regulation of STAT5 has been observed in solid tumors as well as in patients with either chronic or acute myeloid leukemia. Kinase inhibitors are currently being developed to negatively regulate STAT5 activity for clinical purposes.
信号转导及转录激活因子5（STAT5）的活性可被多种细胞因子和生长因子诱导，从而导致特定靶基因的转录激活。STAT5在多种细胞过程中发挥重要作用，包括增殖、分化和凋亡。在实体瘤以及慢性或急性髓系白血病患者中均观察到STAT5的异常调节。目前正在开发激酶抑制剂以负向调节STAT5活性用于临床目的。
