Bingle Colin D, Gorr Sven-U
3Academic Unit of Respiratory Medicine, Division Genomic Medicine, The University of Sheffield Medical School, Royal Hallamshire Hospital, Glossop Road, M128, Floor M, Sheffield S10 2JF, UK.
Int J Biochem Cell Biol. 2004 Nov;36(11):2144-52. doi: 10.1016/j.biocel.2004.05.002.
The innate immune response is of pivotal importance in defending the mucosal barriers of the body against pathogenic attack. The list of proteins that contribute to this defense mechanism is constantly being updated. In this review we introduce a novel family of secreted proteins, palate, lung, and nasal epithelium clones (PLUNCs), that are expressed in the mouth, nose and upper airways of humans, mice, rats and cows. In humans, PLUNC genes are located in a compact cluster on chromosome 20, with similar loci being found in synteneic locations in other species. The protein products of this gene cluster are predicted to be structural homologues of the human lipopolysaccharide binding proteins, lipopolysaccharide binding-protein (LBP) and bacterial permeability-increasing protein (BPI), which are known mediators of host defense against Gram-negative bacteria. On the basis of these observations we outline why we believe PLUNC proteins mediate host defense functions in the oral, nasal and respiratory epithelia.
先天性免疫反应对于保护身体的黏膜屏障免受病原体攻击至关重要。有助于这种防御机制的蛋白质清单一直在不断更新。在本综述中，我们介绍了一个新的分泌蛋白家族，即腭、肺和鼻上皮克隆蛋白（PLUNCs），它们在人类、小鼠、大鼠和牛的口腔、鼻腔和上呼吸道中表达。在人类中，PLUNC基因位于20号染色体上的一个紧密簇中，在其他物种的同线位置也发现了类似的基因座。该基因簇的蛋白质产物预计是人类脂多糖结合蛋白、脂多糖结合蛋白（LBP）和细菌通透性增加蛋白（BPI）的结构同源物，它们是已知的宿主抵御革兰氏阴性菌的介质。基于这些观察结果，我们概述了我们认为PLUNC蛋白在口腔、鼻腔和呼吸道上皮中介导宿主防御功能的原因。
