Forrester M B, Merz R D
Hawaii Birth Defects Program, #208, 76 North King Street, Honolulu, HI 96817-5157, USA.
Public Health. 2004 Sep;118(6):434-8. doi: 10.1016/j.puhe.2003.12.017.
Atresia and stenosis are some of the most common birth defects affecting the small intestine. Few population-based studies have examined the epidemiology of small intestinal atresia/stenosis. Eighty-two cases of small intestinal atresia/stenosis were identified through a population-based birth defects registry in Hawaii during 1986-2000. The relationships of various clinical and demographic factors with small intestinal atresia/stenosis and duodenal atresia/stenosis were examined. The small intestinal atresia/stenosis and duodenal atresia/stenosis rates were 2.9 per 10,000 live births [95% confidence interval (CI) 2.3-3.6] and 1.3 per 10,000 live births (95% CI 1.0-1.9), respectively. No secular trend was observed (P = 0.067 and 0.090, respectively). Maternal age risk for small intestinal atresia/stenosis was U-shaped, while duodenal atresia/stenosis rates were highest with maternal age of 35 years or more. Small intestinal atresia/stenosis was substantially more common among Far East Asians than Caucasians [rate ratio (RR) 1.96, 95% CI 1.24-2.94]. Duodenal atresia/stenosis risk was higher in Hawaii County than in Honolulu County (RR 2.55, 95% CI 1.10-5.02). Small intestinal atresia/stenosis was also associated with low birth weight (RR 11.50, 95% CI 8.05-15.92), low gestational age (RR 8.60, 95% CI 6.34-11.41) and multiple births (RR 3.79, 95% CI 1.39-8.24). In conclusion, this study found associations between small intestinal atresia/stenosis and maternal age, maternal race/ethnicity, county of residence, birth weight, gestational age and plurality, but not delivery period. Many of the associations between small intestinal atresia/stenosis and other factors noted in this investigation were similar to those reported by other studies.
闭锁和狭窄是影响小肠的一些最常见的出生缺陷。很少有基于人群的研究调查小肠闭锁/狭窄的流行病学情况。1986年至2000年期间，通过夏威夷一个基于人群的出生缺陷登记处确定了82例小肠闭锁/狭窄病例。研究了各种临床和人口统计学因素与小肠闭锁/狭窄以及十二指肠闭锁/狭窄之间的关系。小肠闭锁/狭窄和十二指肠闭锁/狭窄的发生率分别为每10000例活产2.9例[95%置信区间（CI）2.3 - 3.6]和每10000例活产1.3例（95%CI 1.0 - 1.9）。未观察到长期趋势（P值分别为0.067和0.090）。小肠闭锁/狭窄的母亲年龄风险呈U形，而十二指肠闭锁/狭窄发生率在母亲年龄35岁及以上时最高。小肠闭锁/狭窄在远东亚洲人中比高加索人更常见[率比（RR）1.96，95%CI 1.24 - 2.94]。夏威夷县的十二指肠闭锁/狭窄风险高于檀香山县（RR 2.55，95%CI 1.10 - 5.02）。小肠闭锁/狭窄还与低出生体重（RR 11.50，95%CI 8.05 - 15.92）、低孕周（RR 8.60，95%CI 6.34 - 11.41）和多胎妊娠（RR 3.79，95%CI 1.39 - 8.24）相关。总之，本研究发现小肠闭锁/狭窄与母亲年龄、母亲种族/民族、居住县、出生体重、孕周和产次有关，但与分娩时期无关。本调查中指出的小肠闭锁/狭窄与其他因素之间的许多关联与其他研究报告的相似。
