Kerr Natalie C
Department of Ophthalmology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
J AAPOS. 2004 Aug;8(4):349-56. doi: 10.1016/j.jaapos.2004.04.005.
Fat adherence syndrome (FAS) is a permanent restrictive strabismus that can occur after periocular surgery or trauma. The pathophysiology is poorly characterized.
Under varying conditions, fat autografts were secured with dissolvable sutures between the inferior rectus and the periosteum of the inferior orbital rim in both eyes of 15 New Zealand white rabbits. Sutures without fat autografts were placed in both eyes of three control rabbits. The force required to move the eyeball superiorly 4, 6, or 8 mm was measured with a digital strain gauge preoperatively and 6 weeks after surgery. Twelve of the 15 rabbits with autografts were then sacrificed, and exenteration specimens were taken. The three remaining rabbits (six eyes) were observed for 6 months after placement of fat autografts.
Analysis of variance allowed rejection of the null hypothesis that there was no difference among the postsurgical groups for all deflection points when 6 weeks postoperative was compared to baseline (preoperative) measurements (P < or = 0.05). Regression analyses showed that stiffness at each deflection was dependent on the amount of fat placed in the orbit. In three rabbits observed for 6 months, restriction tended to be stable over the 6-month observation period and was not alleviated by lysis of adhesions or removal of the fat grafts.
A fat autograft introduced into an extraocular wound in rabbits will produce a permanent restrictive strabismus. This model may prove useful in the study of FAS.
脂肪粘连综合征（FAS）是一种永久性限制性斜视，可发生于眼周手术或外伤后。其病理生理学特征尚不明确。
在不同条件下，用可吸收缝线将自体脂肪移植片固定于15只新西兰白兔双眼的下直肌与眶下缘骨膜之间。在3只对照兔的双眼放置无自体脂肪移植片的缝线。术前及术后6周，用数字应变仪测量将眼球向上移动4、6或8毫米所需的力。然后对15只接受自体脂肪移植的兔子中的12只实施安乐死，并获取眶内容剜除标本。对其余3只兔子（6只眼）在植入自体脂肪移植片后观察6个月。
方差分析表明，将术后6周与基线（术前）测量结果进行比较时，对于所有偏斜点，各手术组之间无差异这一原假设被拒绝（P≤0.05）。回归分析显示，每个偏斜点的僵硬程度取决于眼眶内所放置脂肪的量。在观察6个月的3只兔子中，限制在6个月观察期内趋于稳定，且未因粘连松解或脂肪移植片移除而缓解。
将自体脂肪移植片植入兔眼外伤口会导致永久性限制性斜视。该模型可能在脂肪粘连综合征的研究中被证明有用。
