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伪白喉棒状杆菌机会性物种在社区获得性肺炎(CAP)发病机制中的作用。

The role of opportunistic species of Corynebacterium pseudodiphtheriticum in the pathogenesis of CAP (Community Acquired Pneumonia).

作者信息

Chudnicka Alina, Szmygin-Milanowska Katarzyna, Kieszko Robert, Milanowski Janusz, Kozioł-Montewka Maria

机构信息

Department of Clinical Microbiology, Medical University of Lublin, Lublin, Poland.

出版信息

Ann Univ Mariae Curie Sklodowska Med. 2003;58(1):142-8.

PMID:15314974
Abstract

The analysis of eight cases of CAP (Community Acquired Pneumonia) was performed. The clinical samples of sputum were obtained from patients at which C. pseudodiphtheriticum strains were isolated in the quantity indicating the etiologic agent of infection. In two patients, K. pneumoniae and S. aureus were isolated simultaneously. They were considered as coexisting in the infection. C. pseudodiphtheriticum strains were highly susceptible to antibiotics. They were resistant to Erythromycin (87.5%), Clindamycin (87.5%), Lincomycin (75.5%), Trimeth./Sulfam.(37.5%), Chloramfenicol (37.5%). In the examined group of patients (five persons), the infection with C. pneumoniae was detected as recently passed or in progress with chronic character as the high level of specific antibodies (IgG or IgG and IgA) was present. That fact could predispose to infection with the opportunistic species of C. pseudodiphtheriticum. Of all the examined patients, three were infected with C. pseudodiphtheriticum as the only species responsible for infection (CAP).

摘要

对8例社区获得性肺炎(CAP)病例进行了分析。痰液临床样本取自分离出假白喉棒状杆菌菌株且数量表明为感染病原体的患者。在两名患者中,同时分离出肺炎克雷伯菌和金黄色葡萄球菌。它们被认为在感染中共存。假白喉棒状杆菌菌株对抗生素高度敏感。它们对红霉素(87.5%)、克林霉素(87.5%)、林可霉素(75.5%)、甲氧苄啶/磺胺甲恶唑(37.5%)、氯霉素(37.5%)耐药。在所检查的患者组(5人)中,由于存在高水平的特异性抗体(IgG或IgG和IgA),检测到肺炎衣原体感染为近期发生或呈慢性进展。这一事实可能使患者易感染假白喉棒状杆菌这种机会性菌种。在所有接受检查的患者中,有3人感染假白喉棒状杆菌,且该菌是唯一导致感染(CAP)的菌种。

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