Bercot Eric A, Rovis Tomislav
Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.
J Am Chem Soc. 2004 Aug 25;126(33):10248-9. doi: 10.1021/ja046528b.
Monoalkylation of cyclic anhydrides provides an opportunity to couple a carbon-carbon bond-forming event with the control of backbone stereochemistry. We have developed a palladium-JOSIPHOS catalyst system that desymmetrizes meso-succinic anhydrides using organozinc reagents as nucleophiles, and have found that, in many cases, this reaction proceeds at ambient temperature.
环状酸酐的单烷基化提供了一个将碳-碳键形成过程与主链立体化学控制相结合的机会。我们开发了一种钯-JOSIPHOS催化剂体系，该体系使用有机锌试剂作为亲核试剂使内消旋琥珀酸酐去对称化，并且发现在许多情况下，该反应在室温下即可进行。
