Burt Vivien K
Department of Psychiatry and Biobehavioral Sciences, the David Geffen School of Medicine at UCLA and Women's Life Center at UCLA, USA.
J Clin Psychiatry. 2004;65 Suppl 12:20-5.
Depression includes a wide range of symptoms that can impair a person's psychosocial and physical functioning. This impairment can lead to decreased productivity, increased health care utilization, alcohol and substance abuse, and an increased risk of suicide. While the treatment of depression has significantly advanced over the past 30 years, there is still room for improvement. Full remission of depressive symptoms is often elusive, and many patients never achieve full relief from their depression despite being regarded as responders to antidepressant treatment. Current treatments for depression tend to focus on emotional symptoms, not the physical and anxious symptoms also associated with depression. However, the physical and anxious symptoms of depression can be serious and sometimes more prominent than the emotional symptoms of depression, especially among special populations such as women. New treatment strategies, such as dual-acting agents and the combination of pharmacotherapy and psychotherapy, target the emotional and anxious symptoms of depression as well as symptoms associated with pain. In order to increase response and remission, depression should be seen as an illness comprising not only emotional symptoms but physical and anxious symptoms as well.
抑郁症包括一系列广泛的症状，这些症状会损害一个人的心理社会功能和身体功能。这种损害会导致生产力下降、医疗保健利用率增加、酒精和药物滥用，以及自杀风险增加。虽然在过去30年里抑郁症的治疗有了显著进展，但仍有改进的空间。抑郁症状的完全缓解往往难以实现，许多患者尽管被视为对抗抑郁治疗有反应，但从未完全摆脱抑郁症。目前的抑郁症治疗往往侧重于情绪症状，而不是与抑郁症相关的身体和焦虑症状。然而，抑郁症的身体和焦虑症状可能很严重，有时比抑郁症的情绪症状更突出，尤其是在女性等特殊人群中。新的治疗策略，如双效药物以及药物治疗和心理治疗的联合使用，针对抑郁症的情绪和焦虑症状以及与疼痛相关的症状。为了提高反应率和缓解率，抑郁症应被视为一种不仅包括情绪症状，还包括身体和焦虑症状的疾病。
