与HIV感染相关的口腔组织胞浆菌病：一项对比研究。
Oral histoplasmosis associated with HIV infection: a comparative study.
作者信息
Hernández S L, López De Blanc S A, Sambuelli R H, Roland H, Cornelli C, Lattanzi V, Carnelli M A
机构信息
Clinical Stomatology B, School of Dentistry, National University of Córdoba, Córdoba, Argentina.
出版信息
J Oral Pathol Med. 2004 Sep;33(8):445-50. doi: 10.1111/j.1600-0714.2004.00183.x.
OBJECTIVE
Histoplasmosis is a granulomatous fungal disease caused by Histoplasma capsulatum. The objective of the present paper was to describe the prevalence of oral histoplasmosis (OH) in two services from an endemic area in Argentina between 1991 and 2002 and to compare the clinicopathological profile of OH between HIV-positive and HIV-negative patients.
METHODS
About 733 HIV+ (group A) and 14 260 patients (group B) were examined. Clinical diagnosis was confirmed by cytology, biopsy or culture.
RESULTS
About 21 (3%) and 10 (0.07%) cases of OH were diagnosed in group A and B respectively. Most patients were male. A total of 90% of patients in group A were <45 years old whereas 70% of group B were more than 45 years old. Palate, gingiva and oropharynx were the most frequent locations. The importance of including histoplasmosis in the differential diagnosis of ulcerated oral lesions in immunocompromised patients was discussed.
目的
组织胞浆菌病是由荚膜组织胞浆菌引起的一种肉芽肿性真菌病。本文的目的是描述1991年至2002年期间阿根廷一个疫区的两个医疗机构中口腔组织胞浆菌病（OH）的患病率，并比较HIV阳性和HIV阴性患者OH的临床病理特征。
方法
对约733例HIV阳性患者（A组）和14260例患者（B组）进行了检查。通过细胞学、活检或培养确诊临床诊断。
结果
A组和B组分别诊断出约21例（3%）和10例（0.07%）OH病例。大多数患者为男性。A组90%的患者年龄小于45岁，而B组70%的患者年龄超过45岁。腭、牙龈和口咽是最常见的发病部位。讨论了在免疫功能低下患者溃疡性口腔病变的鉴别诊断中纳入组织胞浆菌病的重要性。
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