Chen Yen-Yu, Lirng Jiing-Feng, Fuh Jong-Ling, Chang Feng-Chi, Cheng Hui-Cheng, Wang Shuu-Jiun
The Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Cephalalgia. 2004 Sep;24(9):694-9. doi: 10.1111/j.1468-2982.2004.00739.x.
The aetiology of primary cough headache (PCH) is obscure. The aim of this study was to investigate the magnetic resonance (MR) morphometric characteristics of the posterior cranial fossa (PCF) in patients with PCH. Eighteen consecutive patients with PCH (14M/4F, mean age 75.1 +/- 6.0 years) and 18 sex- and age-matched control subjects were recruited for study. Based on the midline sagittal MR images, parameters indicating posterior fossa crowdedness were measured. Compared with controls, patients with PCH had a similar size of hindbrain tissue area but a significantly smaller PCF area, resulting in a higher mean hindbrain/PCF ratio (0.78 +/- 0.04 vs. 0.73 +/- 0.06, P = 0.005). In addition, these patients also had a lower position of the cerebellar tonsillar tip, a shorter clivus length and shorter distances from the clivus to the mid-pons and from the basion to the medulla than the control group. Patients with PCH were associated with a more crowded PCF, which might be a contributing factor for the pathogenesis of this headache syndrome.
原发性咳嗽性头痛（PCH）的病因尚不明确。本研究旨在调查PCH患者后颅窝（PCF）的磁共振（MR）形态学特征。连续纳入18例PCH患者（男14例/女4例，平均年龄75.1±6.0岁）和18例年龄及性别匹配的对照者进行研究。基于中线矢状面MR图像，测量提示后颅窝拥挤程度的参数。与对照组相比，PCH患者的后脑组织面积大小相似，但PCF面积显著更小，导致平均后脑/PCF比值更高（0.78±0.04对0.73±0.06，P = 0.005）。此外，这些患者的小脑扁桃体尖端位置更低，斜坡长度更短，斜坡至脑桥中部以及颅底至延髓的距离也比对照组短。PCH患者与PCF更为拥挤有关，这可能是该头痛综合征发病机制的一个促成因素。
