Polizopoulou Z S, Koutinas A F, Souftas V D, Kaldrymidou E, Kazakos G, Papadopoulos G
Laboratory of Clinical Diagnosis and Clinical Pathology, School of Veterinary Medicine, Aristotle University of Thessaloniki, Stavrou Voutyra 11, 546 27 Thessaloniki, Greece.
J Vet Med A Physiol Pathol Clin Med. 2004 Jun;51(5):226-31. doi: 10.1111/j.1439-0442.2004.00633.x.
Ten dogs with primary (n = 8) and metastatic (n = 2) brain tumours were studied in an attempt to evaluate the diagnostic sensitivity of computed tomography (CT) or magnetic resonance imaging (MRI). Of the clinical signs noticed, seizures (seven of 10), behavioural abnormalities and cognition dysfunction (seven of 10), compulsive walking and circling (six of 10), sensorimotor (five of 10) and neuro-opthalmological (two of 10) dysfunction were the most common. In all 10 animals that finally died of the disease or were killed, the histopathological diagnosis that followed necropsy was taken as a golden standard in the CT or MRI prediction of the histological type of brain neoplasms. In every instance, tumour detection, morphology and histological differentiation were possible with the aid of either CT (seven of 10) or MRI (three of 10) imaging especially after contrast enhancement. Only one CT-evaluated dog, diagnosed as meningioma, was found to be astrocytoma on histopathology. Interestingly, a rare case of cerebellar medulloblastoma was correctly identified in MRI scans.
对10只患有原发性（n = 8）和转移性（n = 2）脑肿瘤的犬进行了研究，以评估计算机断层扫描（CT）或磁共振成像（MRI）的诊断敏感性。在观察到的临床症状中，癫痫发作（10只中有7只）、行为异常和认知功能障碍（10只中有7只）、强迫性行走和转圈（10只中有6只）、感觉运动功能障碍（10只中有5只）和神经眼科功能障碍（10只中有2只）最为常见。在最终死于该病或被安乐死的所有10只动物中，尸检后的组织病理学诊断被视为CT或MRI预测脑肿瘤组织学类型的金标准。在每种情况下，借助CT（10只中有7只）或MRI（10只中有3只）成像，尤其是在增强造影后，都可以检测到肿瘤、观察其形态并进行组织学鉴别。在组织病理学检查中，仅1只经CT评估诊断为脑膜瘤的犬被发现为星形细胞瘤。有趣的是，在MRI扫描中正确识别出1例罕见的小脑髓母细胞瘤病例。
