Yale Jean-François
McGill Nutrition Centre, Royal Victoria Hospital, McGill University, 687 Pine Avenue West, Montreal, Que., Canada H3A 1A1.
Diabetes Res Clin Pract. 2004 Sep;65 Suppl 1:S41-6. doi: 10.1016/j.diabres.2004.07.007.
While use of intensive insulin therapy has proven effective for reducing risk of long-term complications of hyperglycemia in people with diabetes, overnight hypoglycemia remains a significant barrier to intensive therapy. Findings from numerous studies indicate that nocturnal hypoglycemia is a frequent event among patients with type 1 diabetes, while severe hypoglycemic episodes are approximately three times more likely in patients on intensive insulin therapy than in those on conventional therapy. Nocturnal hypoglycemia remains frequent, even when specific approaches-use of short-acting insulin analogues to manage postprandial glucose surges, peakless long-acting insulin analogues as basal therapy, and strategically selected bedtime snacks-aim to avert this problem. Thus, nocturnal hypoglycemia continues to threaten the well-being of patients with diabetes and cause concerns for their family members and caregivers. Continuing research is required to improve methods for detection and prompt correction of hypoglycemia in order to achieve a safe level of euglycemia in people with diabetes.
虽然强化胰岛素治疗已被证明对降低糖尿病患者高血糖长期并发症的风险有效，但夜间低血糖仍然是强化治疗的一个重大障碍。大量研究结果表明，夜间低血糖在1型糖尿病患者中是常见事件，而强化胰岛素治疗的患者发生严重低血糖事件的可能性比接受传统治疗的患者大约高三倍。即使采用特定方法——使用短效胰岛素类似物来控制餐后血糖高峰、使用无峰值长效胰岛素类似物作为基础治疗以及策略性选择睡前小吃——旨在避免这个问题，夜间低血糖仍然很常见。因此，夜间低血糖继续威胁糖尿病患者的健康，并引起其家庭成员和护理人员的担忧。需要持续研究以改进低血糖的检测方法和及时纠正措施，从而使糖尿病患者达到安全的血糖正常水平。
