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循环整合素：α5β1、α6β4和Mac-1，但不包括α3β1、α4β1或淋巴细胞功能相关抗原-1（LFA-1）。

Circulating integrins: alpha 5 beta 1, alpha 6 beta 4 and Mac-1, but not alpha 3 beta 1, alpha 4 beta 1 or LFA-1.

作者信息

Bretscher M S

机构信息

Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK.

出版信息

EMBO J. 1992 Feb;11(2):405-10. doi: 10.1002/j.1460-2075.1992.tb05068.x.

DOI:10.1002/j.1460-2075.1992.tb05068.x
PMID:1531629
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC556468/
Abstract

The alpha 5 beta 1, alpha 6 beta 4 and Mac-1 integrins all participate in the endocytotic cycle. By contrast, alpha 3 beta 1, alpha 4 beta 1 and LFA-1 do so much more slowly, or not at all, in the cell lines examined. This indicates that the alpha-chains appear to determine whether an integrin cycles or not, and that alpha 5 beta 1, alpha 6 beta 4 and Mac-1 can be brought to the leading edge of a moving cell by endocytosis and recycling.

摘要

α5β1、α6β4和Mac-1整合素均参与内吞循环。相比之下，在检测的细胞系中，α3β1、α4β1和淋巴细胞功能相关抗原-1（LFA-1）的内吞循环速度要慢得多，或者根本不发生内吞循环。这表明α链似乎决定了整合素是否进行循环，并且α5β1、α6β4和Mac-1可以通过内吞作用和再循环被带到移动细胞的前沿。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0755/556468/3e6438b42f6a/emboj00087-0039-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0755/556468/9f3e57141dfd/emboj00087-0037-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0755/556468/633dfcd5b672/emboj00087-0037-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0755/556468/c85f00fd4484/emboj00087-0037-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0755/556468/b9dd2c9709cc/emboj00087-0037-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0755/556468/47ff8a914e2e/emboj00087-0038-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0755/556468/c10bdd72d46b/emboj00087-0039-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0755/556468/c34d88b18c96/emboj00087-0039-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0755/556468/fbe7c7249ec5/emboj00087-0039-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0755/556468/3e6438b42f6a/emboj00087-0039-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0755/556468/9f3e57141dfd/emboj00087-0037-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0755/556468/633dfcd5b672/emboj00087-0037-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0755/556468/c85f00fd4484/emboj00087-0037-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0755/556468/b9dd2c9709cc/emboj00087-0037-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0755/556468/47ff8a914e2e/emboj00087-0038-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0755/556468/c10bdd72d46b/emboj00087-0039-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0755/556468/c34d88b18c96/emboj00087-0039-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0755/556468/fbe7c7249ec5/emboj00087-0039-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0755/556468/3e6438b42f6a/emboj00087-0039-d.jpg

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