Bryan J P, Sjogren M H, Macarthy P, Cox E, Legters L J, Perine P L
Uniformed Services University of the Health Sciences, Bethesda, MD 20814-5100.
Vaccine. 1992;10(1):33-8. doi: 10.1016/0264-410x(92)90416-h.
To determine the duration of antibody after low-dose, intradermal (i.d.), plasma-derived hepatitis B vaccination and the response to a booster dose, we studied two classes of medical students who were immunized with 2 micrograms doses i.d. In one class, 73/88 (85%) who had been immunized by skilled personnel at 0, 1 and 6 months, had protective concentrations (greater than or equal to 10 mIU ml-1) of anti-HBs at 20 months after the first dose. Twelve (92%) out of 13 students who received only two doses at 0 and 1 months also had protective concentrations at month 20. At month 27, 11/16 (69%) with antibody less than or equal to 10 mIU ml-1 responded to a fourth dose of 2 micrograms i.d. with protective concentrations of anti-HBs. In the second class, after three doses of vaccine at 0, 1, and 6 months, protective concentrations of anti-HBs were present in 90/93 (97%) at 14 months and in 71/80 (89%) at 25 months. In those who received only two doses, protective concentrations were found in 24/31 (74%) at 14 months and 9/16 (56%) at 25 months. After a booster dose of 2 micrograms i.d. at month 25, anti-HBs concentrations rose from a geometric mean of 78 to 1198 mIU ml-1 in 60 subjects previously immunized with three doses and from 18 to 1054 mIU ml-1 in 16 students previously immunized with only two doses. Overall, 73/76 (96%) of students in the second group had protective concentrations of antibody after the booster dose.(ABSTRACT TRUNCATED AT 250 WORDS)
为了确定低剂量皮内注射血浆源性乙肝疫苗后抗体的持续时间以及对加强剂量的反应，我们研究了两类接受2微克皮内注射剂量免疫的医学生。在一个班级中，88名学生中有73名（85%）在0、1和6个月时由技术熟练的人员进行免疫接种，在首剂接种后20个月时抗-HBs浓度达到保护性水平（大于或等于10 mIU/ml）。在0和1个月仅接种两剂的13名学生中有12名（92%）在第20个月时也有保护性浓度。在第27个月时，16名抗-HBs小于或等于10 mIU/ml的学生中有11名（69%）对第四剂2微克皮内注射有反应，产生了保护性抗-HBs浓度。在第二个班级中，在0、1和6个月接种三剂疫苗后，14个月时93名中有90名（97%）抗-HBs达到保护性浓度，25个月时80名中有71名（89%）。在仅接种两剂的学生中，14个月时31名中有24名（74%），25个月时16名中有9名（56%）发现有保护性浓度。在25个月时给予2微克皮内注射加强剂量后，60名先前接种三剂的受试者抗-HBs浓度从几何平均值78上升至1198 mIU/ml，16名先前仅接种两剂的学生从18上升至1054 mIU/ml。总体而言，第二组76名学生中有73名（96%）在加强剂量后抗体达到保护性浓度。（摘要截短于250字）
