Mentro Anne M
The Ohio State University College of Nursing, Atlanta, GA 30350, USA.
Neonatal Netw. 2004 Jul-Aug;23(4):19-23. doi: 10.1891/0730-0832.23.4.19.
Vitamin A is a crucial antioxidant for preterm infants because it protects the lungs from oxidative damage induced by the administration of supplemental oxygen. Although all preterm infants are born with smaller vitamin A stores than full-term infants, the store of vitamin A in preterm infants at risk for bronchopulmonary dysplasia (BPD) is often especially deficient. Despite the increases in plasma vitamin A concentrations that have been achieved with vitamin A supplementation, only modest improvements in clinical outcomes and incidence of BPD have been noted in this population. This article reviews the research on vitamin A supplementation for preterm infants, as well as the issues and clinical implications associated with this intervention.
维生素A是早产儿至关重要的抗氧化剂，因为它能保护肺部免受补充氧气所引起的氧化损伤。尽管所有早产儿出生时的维生素A储备都比足月儿少，但有支气管肺发育不良（BPD）风险的早产儿的维生素A储备往往尤其不足。尽管补充维生素A已使血浆维生素A浓度有所升高，但该人群的临床结局和BPD发病率仅得到适度改善。本文综述了关于早产儿补充维生素A的研究，以及与该干预措施相关的问题和临床意义。
