Amill Alejandro, Gómez María De Los A, Fernández Diana M, Bangdiwala Shrikant I, Ríos Eddy, Hunter Robert F
Retrovirus Research Center, Internal Medicine Department, Universidad Central de Caribe, Puerto Rico 00956.
Addiction. 2004 Sep;99(9):1147-56. doi: 10.1111/j.1360-0443.2004.00812.x.
To describe and assess the changing trends in socio-demographic, risk, clinical and immunological parameters in male intravenous drug users (IDU) with AIDS.
DESIGN, SETTING AND PARTICIPANTS: Baseline description by year of entry of 610 male IDU with AIDS who entered into a cohort study in Bayamón, Puerto Rico, from 1992 to 2000. Study participants were evaluated at in-patient health-care facilities in the University Hospital Ramón Ruiz Arnau or in the ambulatory immunology clinic facilities.
The median age at which subjects entered the study and the proportion of patients with an educational level lower than a high school degree increased from 1992 to 2000. Upward trends were also observed in the practice of injecting non-prescription drugs during the last 12-month period, the practice of needle sharing and the use of a combination of heroin and cocaine ('speedballs'). Higher proportions of subjects were also diagnosed with wasting syndrome and bacterial pneumonia. The median CD4 count recorded at entry decreased over the course of the study.
Puerto Rican male IDU diagnosed with AIDS are arriving at health-care facilities in the latest stages of the disease. Better and early interventions with different health care approaches need to be developed.
描述并评估患有艾滋病的男性静脉吸毒者在社会人口统计学、风险、临床及免疫学参数方面的变化趋势。
设计、地点和参与者：对1992年至2000年在波多黎各巴亚蒙市进入队列研究的610名患有艾滋病的男性静脉吸毒者按入组年份进行基线描述。研究参与者在拉蒙·鲁伊斯·阿尔瑙大学医院的住院医疗设施或门诊免疫学诊所设施接受评估。
从1992年到2000年，受试者进入研究的中位年龄以及教育水平低于高中学历的患者比例有所增加。在过去12个月内注射非处方药的行为、共用针头的行为以及使用海洛因和可卡因混合剂（“速球”）的行为也呈上升趋势。被诊断患有消瘦综合征和细菌性肺炎的受试者比例也更高。研究过程中，入组时记录的CD4细胞计数中位数有所下降。
被诊断患有艾滋病的波多黎各男性静脉吸毒者在疾病的最晚阶段才前往医疗保健机构。需要制定采用不同医疗保健方法的更好的早期干预措施。
