Bruguerolle B, Valli M, Jadot G, Rakoto J C, Bouyard P
C R Seances Soc Biol Fil. 1978;172(3):498-504.
A circadian variation in the curarizing ability of pancuronium bromide (Pavulon) has been documented in an homogenous group of 100 Wistar AF-SPF adult male rats anaesthetized by the steroid anaesthetic althesin (Alfatésine, CT 1341). Animals were maintained at 24 +/- 2 degrees C and synchronized with natural light 06.00 to 18.00 and darkness (october 1977). We observed significant circadian rhythms for both of these agents: first the induction of anaesthesia by althesin was markedly pronounced at 15.30 and varied with season. Secondly the maximum effect of pancuronium was recorded at 08.00. When rats were anaesthetized by sodium pentobarbital under similar experimental conditions but during a different season (january to may) we observed a similar circadian rhythm for pancuronium. These data indicate that: a) the type of anaesthesia used in the protocol may not be of importance in demonstration of a curarizing rhythm in the rat but, b) the possibility of a seasonal component being present and effecting this rhythm needs to be investigated.
在一组由甾体麻醉剂阿尔泰辛（Alfatésine，CT 1341）麻醉的100只Wistar AF-SPF成年雄性大鼠中，已记录到泮库溴铵（潘龙）的箭毒化能力存在昼夜变化。动物饲养在24±2摄氏度的环境中，并与自然光照同步，光照时间为06:00至18:00，黑暗时间（1977年10月）。我们观察到这两种药物都有明显的昼夜节律：首先，阿尔泰辛诱导麻醉在15:30时明显更显著，且随季节变化。其次，泮库溴铵的最大效应记录在08:00。当大鼠在类似实验条件下但不同季节（1月至5月）用戊巴比妥钠麻醉时，我们观察到泮库溴铵有类似的昼夜节律。这些数据表明：a）实验方案中使用的麻醉类型在证明大鼠箭毒化节律方面可能并不重要，但是，b）需要研究是否存在季节性因素并影响这种节律。
