[单胺氧化酶抑制剂苯乙肼对离体灌注大鼠肝脏中异烟肼乙酰化作用的影响]
[Effect of an MAO inhibitor, phenelzine, on acetylation of isoniazid by isolated perfused rat liver].
作者信息
Notter D, Catau G, Besson S
出版信息
C R Seances Soc Biol Fil. 1978;172(3):529-30.
PMID:153184
Abstract
Phenelzin, a monoamine oxydase inhibitor, administered in vivo, in rats, slowed down the initial velocity of isoniazid acetylation in isolated perfused liver. After in vitro addition in perfusion medium phenelzin decreased as well the initial velocity of acetylation as the total amount of acetylated substrate.
摘要
苯乙肼，一种单胺氧化酶抑制剂，在大鼠体内给药后，减缓了离体灌注肝脏中异烟肼乙酰化的初始速度。在灌注培养基中体外添加苯乙肼后，乙酰化的初始速度以及乙酰化底物的总量均降低。
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