Skuba N D, Shchegolev A I, Zelenov G G, Dan V N
Arkh Patol. 2004 May-Jun;66(3):8-12.
Histotopograms of 28 chemodectomas have been studied. Principal microscopic features of malignancy are as follows: structural atypia (complete in solid or fibrous variants) or partial (alveolar chemodectoma) loss of alveolarity as the most important sign of organotypia; another sign of malignancy is cell cataplasia (cell and nuclear polymorphism, change in nuclear-cytoplasmic relationship in the direction of its increase, nuclear hyperchromatism, appearance of large ungly hyperploid nuclei, mitotic activity of tumour cells in one case. Incomplete angiogenesis characteristic for malignant tumours was also detected. Invasive growth in the majority of chemodectomas in the form of partial growth through the walls of great vessels and ubiquitous growth through the walls of small vessels were present in most chemodectomas. Thus, there is a basis to claim that the chemodectomas studied are malignant tumours although they are characterized by a slow (years) growth and slow progression.
对28例化学感受器瘤的组织拓扑图进行了研究。恶性肿瘤的主要微观特征如下：结构异型性（实性或纤维性变体中完全异型）或部分（肺泡型化学感受器瘤）肺泡结构丧失，这是器官样性的最重要标志；恶性肿瘤的另一个标志是细胞化生（细胞和核多态性、核质关系朝着增加的方向变化、核深染、出现大的非整倍体核、1例肿瘤细胞有丝分裂活性）。还检测到恶性肿瘤特有的不完全血管生成。大多数化学感受器瘤以通过大血管壁的部分生长和通过小血管壁的广泛生长的形式出现浸润性生长。因此，有理由认为所研究的化学感受器瘤是恶性肿瘤，尽管它们的特点是生长缓慢（数年）且进展缓慢。
