Dzemeshkevich S L, Tsyplenkova V G, Samko A N, Kukharchuk V V, Skridlevskaia E A
Arkh Patol. 2004 May-Jun;66(3):31-3.
Light optic and electron microscopic studies were made of endomyocardial biopsies from the right ventricle of 8 patients who had undergone orthotopic transplantation of the heart 7-14 years ago. For this period rejection reaction was not typical, more marked were changes related to transplantation coronary disease and microcirculatory disorders: hibernation of cardiomyocytes (CMC), their apoptosis, interstitial fibrosis, dystrophic alterations of CMC. The results show the CMC pool may be resupplied with pluripotent (stem) cells as well as hibernating CMC which take part in the myocardial activity after myocardial circulation recovery by means of angioplasty and plasmapheresis.
对8例在7至14年前接受原位心脏移植患者的右心室心内膜心肌活检组织进行了光学显微镜和电子显微镜研究。在此期间，排斥反应并不典型，与移植冠状动脉疾病和微循环障碍相关的变化更为明显：心肌细胞冬眠（CMC）、其凋亡、间质纤维化、CMC的营养不良性改变。结果表明，通过血管成形术和血浆置换恢复心肌循环后，多能（干）细胞以及参与心肌活动的冬眠CMC可能会补充CMC池。
