Brenner Colleen A, Edwards Chad R, Carroll Christine A, Kieffaber Paul D, Hetrick William P
Department of Psychology, Indiana University, Bloomington 47405, USA.
Psychophysiology. 2004 Sep;41(5):702-8. doi: 10.1111/j.1469-8986.2004.00206.x.
Although P50 event-related potential (ERP) suppression and acoustic startle prepulse inhibition are conceptualized as measures of sensory and sensorimotor gating, respectively, the relationship between these measures is unclear. In the present study, P50 and prepulse inhibition trials were interleaved in a single testing session to determine their relationship. Thirty-one healthy participants were presented with startle- and P50-eliciting stimuli across six trial blocks. Lead stimuli (i.e., the prepulse to the acoustic startle and the first click in the dual click ERP paradigm) resulted in significant gating, or amplitude attenuation, of responses to the startle probe and second paired click. There were no meaningful correlations between the P50 and prepulse inhibition variables, indicating that P50 suppression and acoustic startle prepulse inhibition measure distinct neural mechanisms. The implications of these findings for operationally defining the psychological construct of gating with these psychophysiological measures are discussed.
尽管P50事件相关电位（ERP）抑制和听觉惊跳前脉冲抑制分别被概念化为感觉门控和感觉运动门控的测量指标，但这些指标之间的关系尚不清楚。在本研究中，P50和前脉冲抑制试验在单个测试环节中交替进行，以确定它们之间的关系。31名健康参与者在六个试验块中接受了引发惊跳和P50的刺激。先导刺激（即听觉惊跳的前脉冲和双点击ERP范式中的第一个点击）导致对惊跳探测和第二个配对点击的反应出现显著的门控或幅度衰减。P50和前脉冲抑制变量之间没有有意义的相关性，这表明P50抑制和听觉惊跳前脉冲抑制测量的是不同的神经机制。讨论了这些发现对于用这些心理生理测量方法在操作上定义门控心理结构的意义。
