Witkowska Anna Maria, Borawska Maria Halina
Department of Food Commodities Science and Technology, Medical Academy, Białystok, Poland.
Eur Cytokine Netw. 2004 Apr-Jun;15(2):91-8.
Soluble intercellular adhesion molecule-1 (sICAM-1) represents a circulating form of ICAM-1 that is constitutively expressed or is inducible on the cell surface of different cell lines. It serves as a counter-receptor for the lymphocyte function-associated antigen (LFA-1). Interaction between ICAM-1, present on endothelial cells, and LFA-1 facilitates leukocyte adhesion and migration across the endothelium. ICAM-1 and its circulating form have been implicated in the development of any number of diseases.
可溶性细胞间黏附分子-1（sICAM-1）是细胞间黏附分子-1的一种循环形式，它在不同细胞系的细胞表面组成性表达或可被诱导表达。它作为淋巴细胞功能相关抗原（LFA-1）的反受体。存在于内皮细胞上的细胞间黏附分子-1与淋巴细胞功能相关抗原-1之间的相互作用促进白细胞黏附并穿过内皮迁移。细胞间黏附分子-1及其循环形式与多种疾病的发生发展有关。
