Saadi H F, Reed R L, Carter A O, Al-Suhaili A R
Department of Internal Medicine, United Arab Emirates University, Al Ain, United Arabic Emirates.
J Clin Densitom. 2004 Fall;7(3):313-8. doi: 10.1385/jcd:7:3:313.
Quantitative ultrasound (QUS) of the calcaneus correlates modestly with axial dual-energy X-ray absorptiometry (DXA). Because bone mineral density (BMD) might be influenced by vitamin D status, we assessed the correlation between both techniques in 56 Arabian women, a population with high prevalence of hypovitaminosis D. The speed of sound (SOS), broadband ultrasound attenuation (BUA), and estimated BMD of the right calcaneus were determined by QUS. Spine and right hip BMD were measured by DXA scan. The serum 25-hydroxyvitamin D (25OHD) level was measured by radioimmunoassay. The correlations of QUS parameters (estimated calcaneal BMD, BUA, and SOS) with spine and hip BMD were modest (r = 0.50, r = 0.53, r = 0.41 for the spine and r = 0.54, r = 0.56, and r = 0.46 for the hip, respectively; p < 0.01 for all comparisons), but stronger in postmenopausal women. All postmenopausal women with low estimated calcaneal BMD (T-score pound -1) had a T-score pound -1 by DXA of the spine or hip. Of the 21 premenopausal women with spine or hip T-score pound -1 who had 25OHD measurements, 20 (95.2%) had levels below 50 nmol/L and 12 (57%) had levels below 30 nmol/L. The subgroup with 25OHD < 30 nmol/L had significantly lower spine (p < 0.01) and hip BMD (p < 0.05) than the subgroup with 25OHD >/= 30 nmol/L. QUS parameters were not significantly different between the two subgroups. The QUS and DXA correlated modestly well in women with prevalent hypovitaminosis D. QUS could be used in postmenopausal women with hypovitaminosis D to identify those at risk for osteoporotic fracture.
跟骨定量超声（QUS）与轴向双能X线吸收法（DXA）的相关性一般。由于骨矿物质密度（BMD）可能受维生素D状态的影响，我们评估了56名阿拉伯女性（维生素D缺乏症患病率较高的人群）中这两种技术之间的相关性。通过QUS测定右跟骨的声速（SOS）、宽带超声衰减（BUA）和估计的BMD。通过DXA扫描测量脊柱和右髋部的BMD。通过放射免疫测定法测量血清25-羟基维生素D（25OHD）水平。QUS参数（估计的跟骨BMD、BUA和SOS）与脊柱和髋部BMD的相关性一般（脊柱的r分别为0.50、0.53、0.41，髋部的r分别为0.54、0.56、0.46；所有比较的p<0.01），但在绝经后女性中更强。所有估计跟骨BMD低（T值≤-1）的绝经后女性，其脊柱或髋部DXA的T值均≤-1。在21名有脊柱或髋部T值≤-1且进行了25OHD测量的绝经前女性中，20名（95.2%）的水平低于50 nmol/L，12名（57%）的水平低于30 nmol/L。25OHD<30 nmol/L的亚组的脊柱BMD（p<0.01）和髋部BMD（p<0.05）显著低于25OHD≥30 nmol/L的亚组。两个亚组之间的QUS参数无显著差异。在维生素D缺乏症普遍存在的女性中，QUS和DXA的相关性一般良好。QUS可用于维生素D缺乏症的绝经后女性，以识别有骨质疏松性骨折风险的人群。
