Díez-Juan Antonio, Castro Claudia, Edo M D, Andrés Vicente
Laboratory of Vascular Biology, Department of Molecular and Cellular Pathology and Therapy, Instituto de Biomedicina de Valencia, Spanish Council for Scientific Research, Valencia, Spain.
Curr Vasc Pharmacol. 2003 Mar;1(1):99-106. doi: 10.2174/1570161033386709.
At homeostasis, vascular cells display a very low proliferative rate and a scant migratory activity. However, hyperplastic growth and locomotion of vascular cells are a hallmark of vascular remodeling during several pathophysiological conditions (e.g., neovascularization, arteriosclerosis and restenosis post-angioplasty). Thus, a better understanding of the molecular mechanisms that control vascular cell proliferation and migration should facilitate the development of novel therapies to treat cardiovascular disease. In this review, we will discuss recent studies implicating the cell cycle regulatory protein p27Kip1 as a key modulator of vascular cell growth and locomotion in vitro and during vascular remodeling in vivo.
在稳态下，血管细胞的增殖率非常低，迁移活性也很微弱。然而，在几种病理生理状况（如新生血管形成、动脉硬化和血管成形术后再狭窄）下，血管细胞的增生性生长和运动是血管重塑的一个标志。因此，更好地理解控制血管细胞增殖和迁移的分子机制，应该有助于开发治疗心血管疾病的新疗法。在这篇综述中，我们将讨论最近的研究，这些研究表明细胞周期调节蛋白p27Kip1是体外血管细胞生长和运动以及体内血管重塑过程中的关键调节因子。
