土耳其一家大学医院革兰氏阴性杆菌呼吸道分离株的抗生素敏感性模式
Antibiotic susceptibility patterns among respiratory isolates of Gram-negative bacilli in a Turkish university hospital.
作者信息
Gonlugur Ugur, Bakici Mustafa Zahir, Akkurt Ibrahim, Efeoglu Tanseli
机构信息
Department of Chest Diseases, Cumhuriyet University Medical School, 58140, Sivas, Turkey.
出版信息
BMC Microbiol. 2004 Aug 22;4:32. doi: 10.1186/1471-2180-4-32.
Abstract
BACKGROUND
Gram-negative bacteria cause most nosocomial respiratory infections. At the University of Cumhuriyet, we examined 328 respiratory isolates of Enterobacteriaceae and Acinetobacter baumanii organisms in Sivas, Turkey over 3 years. We used disk diffusion or standardized microdilution to test the isolates against 18 antibiotics.
RESULTS
We cultured organisms from sputum (54%), tracheal aspirate (25%), and bronchial lavage fluid (21%). The most common organisms were Klebsiella spp (35%), A. baumanii (27%), and Escherichia coli (15%). Imipenem was the most active agent, inhibiting 90% of Enterobacteriaceae and A. baumanii organisms. We considered approximately 12% of Klebsiella pneumoniae and 21% of E. coli isolates to be possible producers of extended-spectrum beta-lactamase. K. pneumoniae isolates of the extended-spectrum beta-lactamase phenotype were more resistant to imipenem, ciprofloxacin, and tetracycline in our study than they are in other regions of the world.
CONCLUSIONS
Our results suggest that imipenem resistance in our region is growing.
摘要
背景
革兰氏阴性菌引起大多数医院获得性呼吸道感染。在居米什哈伊尔大学，我们在3年时间里对土耳其锡瓦斯的328株肠杆菌科细菌和鲍曼不动杆菌的呼吸道分离株进行了检测。我们使用纸片扩散法或标准化微量稀释法来检测这些分离株对18种抗生素的敏感性。
结果
我们从痰液（54%）、气管吸出物（25%）和支气管灌洗液（21%）中培养出细菌。最常见的细菌是克雷伯菌属（35%）、鲍曼不动杆菌（27%）和大肠杆菌（15%）。亚胺培南是最有效的药物，能抑制90%的肠杆菌科细菌和鲍曼不动杆菌。我们认为大约12%的肺炎克雷伯菌和21%的大肠杆菌分离株可能是超广谱β-内酰胺酶的产生菌。在我们的研究中，具有超广谱β-内酰胺酶表型的肺炎克雷伯菌分离株对亚胺培南、环丙沙星和四环素的耐药性比世界其他地区的同类分离株更强。
结论
我们的结果表明，我们所在地区对亚胺培南的耐药性正在增加。
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