Olley B O, Seedat S, Nei D G, Stein D J
MRC Unit on Anxiety Disorders, Department of Psychiatry University of Stellenbosch, Cape Town, South Africa.
AIDS Patient Care STDS. 2004 Aug;18(8):481-7. doi: 10.1089/1087291041703700.
There is increasing evidence that major depression impacts the course of HIV infection, yet few studies have explored demographic and clinical predictors of depression in people who with HIV/AIDS. This study investigated predictors of depression (e.g., demographic and clinical variables, negative life events, and coping response) among outpatients with recently diagnosed HIV/AIDS patients in South Africa. One hundred forty-nine recently diagnosed HIV/AIDS patients (44 males and 105 females; mean time since diagnosis = 5.8, standard deviation [SD] 4.1) were evaluated. Subjects were assessed using the Mini International Neuropsychiatric Interview (MINI), the Carver Brief COPE coping scale, and the Sheehan Disability Scale. In addition, previous exposures to trauma and past risk behaviors were assessed. Three variables: gender (odd ratio [OR] = 1.23; 95% confidence interval [CI] 1.56, 1.93), impact of negative life events (OR = 1.13; CI, 1.03, 1.23), and disability (OR = 1.51, CI, 1.28, 1.80) predicted current major depression. It is well known from non-HIV populations that female gender and increased negative life events predict depression. These data also emphasize the importance of these links in HIV.
越来越多的证据表明，重度抑郁症会影响艾滋病毒感染的病程，但很少有研究探讨艾滋病毒/艾滋病患者抑郁症的人口统计学和临床预测因素。本研究调查了南非近期诊断出的艾滋病毒/艾滋病门诊患者中抑郁症的预测因素（如人口统计学和临床变量、负面生活事件及应对反应）。对149名近期诊断出的艾滋病毒/艾滋病患者（44名男性和105名女性；诊断后的平均时间=5.8，标准差[SD]4.1）进行了评估。使用迷你国际神经精神访谈（MINI）、卡弗简易应对量表和希恩残疾量表对受试者进行评估。此外，还评估了既往创伤暴露和过去的风险行为。三个变量：性别（比值比[OR]=1.23；95%置信区间[CI]1.56，1.93）、负面生活事件的影响（OR=1.13；CI，1.03，1.23）和残疾（OR=1.51，CI，1.28，1.80）可预测当前的重度抑郁症。从非艾滋病毒人群中可知，女性和负面生活事件增加会预测抑郁症。这些数据也强调了这些关联在艾滋病毒患者中的重要性。
