Mencher Jordan S, Smith Susan R, Powell Tim D, Stinchcomb Dan T, Osorio Jorge E, Rocke Tonie E
Wildlife Science Group, University of Washington, Seattle, Washington, USA.
Infect Immun. 2004 Sep;72(9):5502-5. doi: 10.1128/IAI.72.9.5502-5505.2004.
Prairie dogs (Cynomys spp.) are highly susceptible to Yersinia pestis and significant reservoirs of plague for humans in the western United States. A recombinant raccoon poxvirus, expressing the F1 antigen of Y. pestis, was incorporated into a palatable bait and offered to 18 black-tailed prairie dogs (Cynomys ludovicianus) for voluntary consumption; 18 negative control animals received placebo baits. Antibody titers against Y. pestis F1 antigen increased significantly (P < 0.01) in vaccinees, and their survival was significantly higher upon challenge with Y. pestis than that of negative controls (P < 0.01).
草原犬鼠(犬鼠属)对鼠疫耶尔森菌高度易感,是美国西部人类鼠疫的重要宿主。一种表达鼠疫耶尔森菌F1抗原的重组浣熊痘病毒被掺入美味诱饵中,并提供给18只黑尾草原犬鼠(Cynomys ludovicianus)自愿食用;18只阴性对照动物接受安慰剂诱饵。接种疫苗的动物针对鼠疫耶尔森菌F1抗原的抗体滴度显著升高(P < 0.01),并且在用鼠疫耶尔森菌攻击后,它们的存活率显著高于阴性对照(P < 0.01)。