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在自愿食用含有重组浣熊痘病毒疫苗的诱饵后,黑尾土拨鼠(Cynomys ludovicianus)对鼠疫的防护作用。

Protection of black-tailed prairie dogs (Cynomys ludovicianus) against plague after voluntary consumption of baits containing recombinant raccoon poxvirus vaccine.

作者信息

Mencher Jordan S, Smith Susan R, Powell Tim D, Stinchcomb Dan T, Osorio Jorge E, Rocke Tonie E

机构信息

Wildlife Science Group, University of Washington, Seattle, Washington, USA.

出版信息

Infect Immun. 2004 Sep;72(9):5502-5. doi: 10.1128/IAI.72.9.5502-5505.2004.

Abstract

Prairie dogs (Cynomys spp.) are highly susceptible to Yersinia pestis and significant reservoirs of plague for humans in the western United States. A recombinant raccoon poxvirus, expressing the F1 antigen of Y. pestis, was incorporated into a palatable bait and offered to 18 black-tailed prairie dogs (Cynomys ludovicianus) for voluntary consumption; 18 negative control animals received placebo baits. Antibody titers against Y. pestis F1 antigen increased significantly (P < 0.01) in vaccinees, and their survival was significantly higher upon challenge with Y. pestis than that of negative controls (P < 0.01).

摘要

草原犬鼠(犬鼠属)对鼠疫耶尔森菌高度易感,是美国西部人类鼠疫的重要宿主。一种表达鼠疫耶尔森菌F1抗原的重组浣熊痘病毒被掺入美味诱饵中,并提供给18只黑尾草原犬鼠(Cynomys ludovicianus)自愿食用;18只阴性对照动物接受安慰剂诱饵。接种疫苗的动物针对鼠疫耶尔森菌F1抗原的抗体滴度显著升高(P < 0.01),并且在用鼠疫耶尔森菌攻击后,它们的存活率显著高于阴性对照(P < 0.01)。

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