约旦2型糖尿病患者的甲状腺功能障碍

Thyroid dysfunction in patients with type 2 diabetes mellitus in Jordan.

作者信息

Radaideh Abdel-Rahman M, Nusier Mohamad K, Amari Fawaz L, Bateiha Anwar E, El-Khateeb Mohammed S, Naser Abeer S, Ajlouni Kamel M

机构信息

National Center of Diabetes, Endocrinology and Genetics, Jordan University of Science and Technology, School of Medicine, Irbid, Jordan.

出版信息

Saudi Med J. 2004 Aug;25(8):1046-50.

PMID:15322596

Abstract

OBJECTIVE

To investigate the prevalence of thyroid dysfunction and autoimmunity in type 2 diabetic patients.

METHODS

The study was conducted at the National Center for Diabetes, Endocrinology and Genetics, Jordan University Hospital, Amman, Jordan, between March 2000 and September 2000. A group of 908 type 2 diabetic patients (T2DM) were recruited in the study and underwent investigations for thyroid functions; free thyroxine (FT4), free tri-iodothyronine (FT3) and thyroid stimulating hormone (TSH). Six hundred had performed thyroid autoantibodies, thyroid peroxidase antibodies (TPOab) or antimicrosomal antibodies (AMA) and thyroglobulin antibodies (Tgab). They were compared with 304 non-diabetics, of those 282 had performed thyroid antibodies.

RESULTS

Fifty-three (5.9%) of diabetic patients were known to have thyroid disease. As a direct result of screening, new thyroid disease cases were diagnosed in 6.6% of the patients. Thus, the overall prevalence of thyroid disease was found to be 12.5%. The most common was subclinical hypothyroidism (4.1%). In the control group, the prevalence of thyroid disease was 6.6%. The most common was subclinical hypothyroidism (5%). There was a significant difference between diabetics and control subjects p=0.0064. Positive TPOab was found in 8.3% of T2DM patients (N=600) versus 10.3% in the control group (N=282) p=0.412. Positivity for both TPOab and Tgab was found to be 2.5% of T2DM versus 6% of the control subjects p=0.0155.

CONCLUSION

This study suggests that diabetic patients should be screened for asymptomatic thyroid dysfunction.

摘要

目的

调查2型糖尿病患者甲状腺功能障碍和自身免疫的患病率。

方法

该研究于2000年3月至2000年9月在约旦安曼市约旦大学医院国家糖尿病、内分泌与遗传学中心进行。一组908例2型糖尿病患者（T2DM）被纳入研究并接受甲状腺功能检查；游离甲状腺素（FT4）、游离三碘甲状腺原氨酸（FT3）和促甲状腺激素（TSH）。600例患者检测了甲状腺自身抗体、甲状腺过氧化物酶抗体（TPOab）或抗微粒体抗体（AMA）以及甲状腺球蛋白抗体（Tgab）。将他们与304例非糖尿病患者进行比较，其中282例检测了甲状腺抗体。

结果

已知53例（5.9%）糖尿病患者患有甲状腺疾病。作为筛查的直接结果，6.6%的患者被诊断出患有新的甲状腺疾病病例。因此，甲状腺疾病的总体患病率为12.5%。最常见的是亚临床甲状腺功能减退（4.1%）。在对照组中，甲状腺疾病的患病率为6.6%。最常见的是亚临床甲状腺功能减退（5%）。糖尿病患者与对照组之间存在显著差异，p = 0.0064。8.3%的T2DM患者（N = 600）TPOab呈阳性，而对照组为10.3%（N = 282），p = 0.412。T2DM患者中TPOab和Tgab均呈阳性的比例为2.5%，而对照组为6%，p = 0.0155。