Department of Medical Laboratory Science, College of Medicine and Health Sciences, Arba Minch University, P.O. Box 21, Arba Minch, Ethiopia.
Department of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar, Ethiopia.
Syst Rev. 2024 Apr 30;13(1):119. doi: 10.1186/s13643-024-02527-y.
Thyroid dysfunction (TD) and type 2 diabetes mellitus (T2DM) frequently co-occur and have overlapping pathologies, and their risk increases with age. Thyroid dysfunction along with T2DM will worsen macro- and microvascular complications, morbidity, and mortality.
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement guideline was followed. The databases used were Embase, ScienceDirect, PubMed, and Google Scholar. The Joana Briggs Institute (JBI) scale was used to assess the quality of the included studies. The data was extracted by Microsoft Excel and analyzed through STATA version 14 software. The overall pooled prevalence of TD and its main components were estimated using the random-effects model. The consistency of studies was assessed by I test statistics. Pooled meta-logistic regression was used to present the pooled prevalence with a 95% confidence interval (CI). Besides, subgroup and sensitivity analyses were employed.
Thirty-eight studies were included. The pooled prevalence of TD was 20.24% (95% CI: 17.85, 22.64). The pooled prevalence of subclinical hypothyroidism, hypothyroidism, subclinical hyperthyroidism, and hyperthyroidism was found to be 11.87% (95% CI: 6.90, 16.84), 7.75% (95% CI: 5.71, 9.79), 2.49% (95% CI: 0.73, 4.25), and 2.51% (95% CI: 1.89, 3.13), respectively. Subgroup analysis based on continent revealed a higher prevalence of TD in Asia and Africa. Factors like being female, HbA1c ≥ 7%, DM duration > 5 years, family history of TD, central obesity, smoking, the presence of retinopathy, and neuropathy were found associated with TD.
The current systematic review and meta-analysis showed that the TD's pooled prevalence was relatively higher than the general population. Therefore, regular screening of TD should be done for T2DM patients.
甲状腺功能障碍（TD）和 2 型糖尿病（T2DM）经常同时发生，且具有重叠的病理，其风险随着年龄的增长而增加。甲状腺功能障碍加上 T2DM 会加重大血管和微血管并发症、发病率和死亡率。
遵循系统评价和荟萃分析的首选报告项目声明指南。使用的数据库包括 Embase、ScienceDirect、PubMed 和 Google Scholar。使用乔安娜·布里格斯研究所（JBI）量表评估纳入研究的质量。通过 Microsoft Excel 提取数据，并通过 STATA 版本 14 软件进行分析。使用随机效应模型估计 TD 及其主要成分的总体合并患病率。通过 I 检验统计量评估研究的一致性。使用合并 meta-逻辑回归呈现合并患病率及其 95%置信区间（CI）。此外，还进行了亚组和敏感性分析。
纳入了 38 项研究。TD 的合并患病率为 20.24%（95%CI：17.85，22.64）。亚临床甲状腺功能减退、甲状腺功能减退、亚临床甲状腺功能亢进和甲状腺功能亢进的合并患病率分别为 11.87%（95%CI：6.90，16.84）、7.75%（95%CI：5.71，9.79）、2.49%（95%CI：0.73，4.25）和 2.51%（95%CI：1.89，3.13）。基于大陆的亚组分析显示，亚洲和非洲的 TD 患病率较高。女性、HbA1c≥7%、DM 病程>5 年、TD 家族史、中心性肥胖、吸烟、存在视网膜病变和神经病变等因素与 TD 相关。
本系统评价和荟萃分析显示，TD 的合并患病率相对较高，超过了一般人群。因此，应定期对 T2DM 患者进行 TD 筛查。
Zotero 插件
