Pan Bin, Yang Dong-Wei, Han Tai-Zhen
Department of Physiology, School of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Sheng Li Xue Bao. 2004 Aug 25;56(4):451-4.
Long-term potentiation (LTP) can be induced by various tetanic parameters in the mammalian visual cortex. However, little researches have been done on the relationship between the expression of the long-lasting LTP (late phase LTP or L-LTP) lasting more than 3 h and the tetanic parameters. In the present study, the effects of 2 Hz and 100 Hz tetanic parameters on L-LTP of the field potentials were recorded from the layer II/III of the rat visual cortical slices in response to stimulation of the layer IV. As a result, tetanic parameters that had more than 300 pulses reliably induced L-LTP in the postnatal day 15-21 rats. Obviously different L-LTP expressions were induced by 2 Hz and 100 Hz tetani. There was no difference in L-LTP expression induced by the parameters with the same frequency and different total pulses. These data suggest that L-LTPs induced by different frequency parameters may have different induction and maintenance mechanisms; L-LTPs induced by the parameters with the same frequency may have the same mechanisms.
在哺乳动物视觉皮层中，各种强直刺激参数均可诱导长时程增强（LTP）。然而，关于持续超过3小时的长时程LTP（晚期LTP或L-LTP）的表达与强直刺激参数之间的关系，相关研究较少。在本研究中，记录了2 Hz和100 Hz强直刺激参数对大鼠视觉皮层切片II/III层场电位L-LTP的影响，该场电位是对IV层刺激的反应。结果表明，超过300个脉冲的强直刺激参数能可靠地诱导出生后第15 - 21天大鼠的L-LTP。2 Hz和100 Hz强直刺激诱导出的L-LTP表达明显不同。相同频率但不同总脉冲数的参数所诱导的L-LTP表达无差异。这些数据表明，不同频率参数诱导的L-LTP可能具有不同的诱导和维持机制；相同频率参数诱导的L-LTP可能具有相同的机制。
