Extensive proteinuria in rats after single dose of adriamycin--etiology.
作者信息
Pedrycz Agnieszka, Czerny Krystyna, Wieczorski Marcin, Sekita-Krzak Joanna, Cichacz Beata
机构信息
Department and Institute of Histology and Embryology with the Laboratory for Experimental Cytology, Medical University of Lublin.
出版信息
Ann Univ Mariae Curie Sklodowska Med. 2003;58(2):79-85.
PMID:15323170
Abstract
The purpose of the present studies was to find the cause of proteinuria, which is displayed in rats after one dose of adriamycin. The results show electrostatic (decreased amount of negative charges in glomerulus) and morphological damage of kidney filtration barriers, which causes increased permeability of basal membranes for proteins. An important part in etiology seems to played by free radicals, which arise in the process of adriamycin transformation.
摘要
相似文献
1
Extensive proteinuria in rats after single dose of adriamycin--etiology.
Ann Univ Mariae Curie Sklodowska Med. 2003;58(2):79-85.
2
Comparison of methods of inducing experimental nephrotic syndrome in lab animals.
Ann Univ Mariae Curie Sklodowska Med. 2003;58(2):116-20.
3
Glomerulosclerosis 4 weeks after administration of adriamycin in a single dose.单次给予阿霉素4周后的肾小球硬化。
Ann Univ Mariae Curie Sklodowska Med. 2004;59(1):214-9.
4
Administration of pigment epithelium-derived factor (PEDF) reduces proteinuria by suppressing decreased nephrin and increased VEGF expression in the glomeruli of adriamycin-injected rats.给予色素上皮衍生因子（PEDF）可通过抑制阿霉素注射大鼠肾小球中nephrin表达降低和VEGF表达增加来减少蛋白尿。
Nephrol Dial Transplant. 2009 May;24(5):1397-406. doi: 10.1093/ndt/gfn659. Epub 2008 Nov 28.
5
Hiponatremia during pregnancy with adriamycin-induced nephrotic syndrome in rats.妊娠期间大鼠阿霉素诱导的肾病综合征伴低钠血症。
Ann Univ Mariae Curie Sklodowska Med. 2003;58(2):86-90.
6
Studies on the relationship between proteinuria and glomerular ultrastructural change in hyperalbuminaemic female Wistar rats.
J Pathol. 1982 Dec;138(4):365-83. doi: 10.1002/path.1711380407.
7
Changes of negative charge on RBC and glomeruli and its relation to the proteinuria of adriamycin nephrosis in rats.大鼠红细胞和肾小球负电荷变化及其与阿霉素肾病蛋白尿的关系。
Chin Med J (Engl). 1991 Jul;104(7):573-6.
8
Nephrotic syndrome (NS) and pregnancy in rat--evaluation of kidney in electron microscopy.大鼠肾病综合征（NS）与妊娠——肾脏的电子显微镜评估
Ann Univ Mariae Curie Sklodowska Med. 2004;59(1):220-4.
9
Adriamycin-induced nephrotic syndrome in rats: sequence of pathologic events.阿霉素诱导的大鼠肾病综合征：病理事件序列
Lab Invest. 1982 Jan;46(1):16-23.
10
[The status of negative charge of the RBC and glomeruli and its relation to proteinuria in adriamycin nephrosis in rats].[大鼠阿霉素肾病中红细胞和肾小球的负电荷状态及其与蛋白尿的关系]
Zhonghua Yi Xue Za Zhi. 1990 Feb;70(2):91-3, 8.
Zotero 插件