Barud Wojciech, Palusiński Robert, Makaruk Bogusław, Hanzlik Janusz
Department of Internal Medicine, Medical University of Lublin.
Ann Univ Mariae Curie Sklodowska Med. 2003;58(2):241-6.
The effects of three months' transdermal dihydrotestosterone treatment were assessed in eleven men with coronary artery disease. Concentration of total testosterone level significantly decreased (p < 0.01) as well as free testosterone (p < 0.05) and estradiol levels (p < 0.01), without changes of sex hormone binding globuline and estradiol/testosterone ratio. DHT regimen did not alter the parameters of lipid profile. No changes of blood glucose, insulin, insulin resistance (HOMA) and fibrinogen were observed in this group. The tendency towards higher levels of hemoglobin, erythrocyte count and hematocrit did not reach statistical significance. Short term DHT administration in aging males was safe for prostate.
对11名冠心病男性患者进行了为期三个月的经皮双氢睾酮治疗效果评估。总睾酮水平、游离睾酮水平（p < 0.05）和雌二醇水平（p < 0.01）均显著降低，而性激素结合球蛋白和雌二醇/睾酮比值无变化。双氢睾酮治疗方案未改变血脂参数。该组患者的血糖、胰岛素、胰岛素抵抗（HOMA）和纤维蛋白原均无变化。血红蛋白、红细胞计数和血细胞比容升高的趋势未达到统计学意义。老年男性短期使用双氢睾酮对前列腺是安全的。
