Nogués X, Sentí M, Pedro-Botet J, Molina L, Serrat R, Pons S, Rubiés-Prat J
Departamento de Medicina del Hospital del Mar, Barcelona.
Med Clin (Barc). 1992 Feb 8;98(5):171-4.
Lipoprotein (Lp) (a) is considered a risk factor for early coronary heart disease (CHD), and a discriminant cutoff of Lp(a) concentration has been suggested.
Serum Lp(a) concentrations have been determined by enzymoimmunoassay in 66 men with CHD and in 100 healthy control men. Serum cholesterol, serum triglycerides, high density lipoprotein (HDL)-cholesterol, and apoprotein (apo) A-I were also determined.
Serum Lp(a) concentration was 21.7 +/- 16.9 mg/dl (mean +/- SD) in patients and 12.5 +/- 12.5 mg/dl in controls (p less than 0.001). Serum cholesterol was 5.63 +/- 1.22 mmol/l and 5.29 +/- 1.00 mmol/l (p less than 0.05) respectively; serum triglycerides were 1.99 +/- 1.23 mmol/l and 1.29 +/- 0.61 mmol/l (p less than 0.001) respectively; HDL-cholesterol was 0.97 +/- 0.27 mmol/l and 1.07 +/- 0.30 mmol/l (p less than 0.05) respectively; and apo A-I was 94 +/- 15 mg/dl and 144 +/- 41 mg/dl (p less than 0.001) respectively. Lp(a) concentrations were not correlated with other well-recognized cardiovascular risk lipidic factors, nor influenced by age either body mass index. Using 20 mg/dl as discriminant Lp(a) concentration between patients and controls, a ratio 2:1 in patients with respect to controls has been observed and exceeded some more when the threshold level was put on 30 mg/dl. A subset of normocholesterolemic and normotriglyceridemic patients (n = 17) and controls (n = 49) had serum Lp(a) concentration of 22.7 +/- 16.3 mg/dl and 9.1 +/- 8.2 mg/dl (p less than 0.001) respectively.
Increased concentration of Lp(a) constitutes an independent risk factor for CHD. On the other hand, Lp(a) concentrations of 20 mg/dl or 30 mg/dl as risk threshold levels are well-defined.
脂蛋白（a）[Lp（a）]被认为是早期冠心病（CHD）的一个危险因素，并且有人提出了Lp（a）浓度的判别临界值。
采用酶免疫分析法测定了66例冠心病男性患者和100例健康对照男性的血清Lp（a）浓度。同时还测定了血清胆固醇、血清甘油三酯、高密度脂蛋白（HDL）胆固醇和载脂蛋白（apo）A-I。
患者血清Lp（a）浓度为21.7±16.9mg/dl（均值±标准差），对照组为12.5±12.5mg/dl（p<0.001）。血清胆固醇分别为5.63±1.22mmol/l和5.29±1.00mmol/l（p<0.05）；血清甘油三酯分别为1.99±1.23mmol/l和1.29±0.61mmol/l（p<0.001）；HDL胆固醇分别为0.97±0.27mmol/l和1.07±0.30mmol/l（p<0.05）；apo A-I分别为94±15mg/dl和144±41mg/dl（p<0.001）。Lp（a）浓度与其他公认的心血管危险因素脂质无关，也不受年龄和体重指数的影响。以20mg/dl作为患者与对照组之间Lp（a）浓度的判别值时，观察到患者与对照组的比例为2:1，当阈值提高到30mg/dl时，该比例更高。一组血脂正常的患者（n=17）和对照组（n=49）的血清Lp（a）浓度分别为22.7±16.3mg/dl和9.1±8.2mg/dl（p<0.001）。
Lp（a）浓度升高是冠心病的一个独立危险因素。另一方面，20mg/dl或30mg/dl的Lp（a）浓度作为危险阈值水平是明确的。
