Feikin Daniel R, Nelson Christopher B, Watt James P, Mohsni Ezzeddine, Wenger Jay D, Levine Orin S
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Emerg Infect Dis. 2004 Jul;10(7):1270-6. doi: 10.3201/eid1007.030737.
Haemophilus influenzae type b (Hib) still causes a substantial number of deaths among children in developing countries, despite the availability of effective conjugate vaccines. A major obstacle in developing a Hib vaccine has been limited awareness about the impact of Hib disease. A tool was developed to estimate the national rates of Hib meningitis and pneumonia by assessing retrospective local data over 7 to 10 days. Data from 11 countries in Africa, the Middle East, and Asia were studied and showed rates of Hib meningitis from >50 cases per 100,000 children >5 years in Ghana and Uganda to <15 per 100,000 in Iran, Jordan, and Uzbekistan. Results were affected by the quality of available data. The Hib rapid assessment tool can be useful to countries that desire a timely assessment of Hib disease rates.
尽管已有有效的结合疫苗，但b型流感嗜血杆菌（Hib）在发展中国家的儿童中仍导致大量死亡。开发Hib疫苗的一个主要障碍是对Hib疾病影响的认识有限。通过评估7至10天的回顾性本地数据，开发了一种工具来估计全国Hib脑膜炎和肺炎的发病率。对来自非洲、中东和亚洲11个国家的数据进行了研究，结果显示，在加纳和乌干达，每10万名5岁以上儿童中Hib脑膜炎发病率超过50例，而在伊朗、约旦和乌兹别克斯坦，该发病率低于每10万例中的15例。结果受到现有数据质量的影响。Hib快速评估工具对希望及时评估Hib疾病发病率的国家可能有用。
