Lai Wen-Sung, Chen Aiyin, Johnston Robert E
Department of Psychology, Cornell University, Ithaca, NY 14853, USA.
Horm Behav. 2004 Sep;46(3):319-29. doi: 10.1016/j.yhbeh.2004.06.007.
The neural mechanisms underlying recognition of familiar individuals and responses appropriate to them are not well known. Previous studies with male golden hamsters have shown that, after a series of brief aggressive encounters, a loser selectively avoids his own, familiar winner but does not avoid other males. Using this paradigm, we investigated activity in 20 areas of the brain using immunohistochemistry for c-Fos and Egr-1 during exposure to a familiar winner compared to control groups not exposed to another male. Behavioral data showed that 1 day after fights males that lost avoided the familiar winner, suggesting that they recognized this individual. The c-Fos and Egr-1 immunohistochemistry showed that the losers exposed to familiar winners had a greater density of stained cells in the basolateral amygdala, the CA1 region of anterior dorsal hippocampus and the dorsal subiculum than control groups had in these areas. These results suggest that these brain areas may be involved in the memory for other males, the learned fear of familiar winners, or related processes.
识别熟悉个体并做出相应反应背后的神经机制尚不清楚。先前对雄性金黄地鼠的研究表明，在一系列短暂的攻击性行为后，失败者会选择性地避开自己熟悉的胜利者，但不会避开其他雄性。利用这一范式，我们通过免疫组织化学检测c-Fos和Egr-1，研究了20个脑区在接触熟悉的胜利者时的活动情况，并与未接触其他雄性的对照组进行了比较。行为数据显示，打架一天后，失败的雄性会避开熟悉的胜利者，这表明它们认出了这个个体。c-Fos和Egr-1免疫组织化学显示，与对照组相比，接触熟悉胜利者的失败者在基底外侧杏仁核、前背侧海马体的CA1区域和背侧下托中染色细胞的密度更高。这些结果表明，这些脑区可能参与了对其他雄性的记忆、对熟悉胜利者的习得性恐惧或相关过程。
