Mertes P M, de Talancé N, Pinelli G, Villemot J P, Burlet C, Boulangé M
Renal and Metabolic Function Exploration Laboratory, University of Nancy Medical Center (Centre Hospitalier Universitaire de Brabois), France.
Chest. 1992 Apr;101(4):1050-5. doi: 10.1378/chest.101.4.1050.
The purpose of this study was to compare the early postoperative effects of heart and heart-lung transplantation on the secretion of atrial natriuretic peptide (alpha-ANP), renin, aldosterone, and vasopressin. This was carried out from the first to the eighth postoperative day in ten heart and five heart-lung recipients. The changes in the release of these hormones were similar in both groups. Vasopressin release remained stable while that of the renin-angiotensin-aldosterone system progressively returned to more normal levels. Grafted heart tissue was capable of high alpha-ANP release early on in both heart and in heart-lung recipients. This sustained alpha-ANP release was not a function of the resulting overall atrial tissue mass. Our findings suggest that it might be the consequence of an intrinsic hypersecretion of alpha-ANP resulting from the loss of normal heart innervation occurring in both heart and heart-lung transplantation.
本研究的目的是比较心脏移植和心肺移植术后早期对心房利钠肽（α-ANP）、肾素、醛固酮和血管加压素分泌的影响。对10例心脏移植受者和5例心肺移植受者在术后第1天至第8天进行了此项研究。两组中这些激素释放的变化相似。血管加压素释放保持稳定，而肾素-血管紧张素-醛固酮系统的释放逐渐恢复到更正常的水平。在心脏移植受者和心肺移植受者中，移植的心脏组织早期都能够大量释放α-ANP。这种持续的α-ANP释放并非由总的心房组织质量所决定。我们的研究结果表明，这可能是由于心脏移植和心肺移植中正常心脏神经支配丧失导致α-ANP内在分泌过多的结果。
