Mills T P
Arkansas Children's Hospital, Little Rock.
J Ark Med Soc. 1992 Feb;88(9):437-40.
Ramipril is a long acting angiotensin converting enzyme (ACE) inhibitor, which exhibits similar pharmacodynamic properties to Captopril and Enalapril. Like Enalapril, it is a prodrug, which is hydrolyzed after absorption to form the active metabolite ramiprilat which has a long elimination half-life, permitting once daily administration. In the dose range 2.5-10 mg once daily the drug has been effective and well tolerated during treatment for up to two years. In dosages of 5 or 10 mg once daily the antihypertensive efficacy of Ramipril was comparable with usual therapeutic dosages of Captopril, Enalapril, and Atenolol.
雷米普利是一种长效血管紧张素转换酶（ACE）抑制剂，其药效学特性与卡托普利和依那普利相似。与依那普利一样，它是一种前体药物，吸收后被水解形成活性代谢产物雷米普利拉，后者具有较长的消除半衰期，允许每日给药一次。在每日2.5 - 10毫克的剂量范围内，该药物在长达两年的治疗期间有效且耐受性良好。每日5毫克或10毫克的剂量下，雷米普利的降压疗效与卡托普利、依那普利和阿替洛尔的常用治疗剂量相当。
