Hewitt Peter R, Cleator Ed, Ley Steven V
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UKCB2 1EW.
Org Biomol Chem. 2004 Sep 7;2(17):2415-7. doi: 10.1039/B410180D. Epub 2004 Aug 9.
The first total synthesis of (+)-okaramine C is described. Our previously described selenocyclisation-oxidative deselenation sequence was used to establish a 3a-hydroxy-pyrrolo[2,3-b]indole core, which was modified by selective epimerisation to the common pyrrolo[2,3-b]indole of the okaramines.
描述了(+)-奥卡拉明C的首次全合成。我们之前描述的硒环化-氧化脱硒序列被用于构建一个3a-羟基-吡咯并[2,3-b]吲哚核心，该核心通过选择性差向异构化转化为奥卡拉明常见的吡咯并[2,3-b]吲哚。
