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产后晚期妇女发生的伴有腹膜后受累的A组链球菌产褥期败血症:病例报告

Group A streptococcal puerperal sepsis with retroperitoneal involvement developing in a late postpartum woman: case report.

作者信息

Okumura Keiko, Schroff Richard, Campbell Rwanda, Nishioka Lucas, Elster Eric

机构信息

Department of Surgery, United States Naval Hospital Yokosuka, Japan.

出版信息

Am Surg. 2004 Aug;70(8):730-2.

Abstract

Group A beta-hemolytic streptococci cause a wide range of infectious diseases such as pharyngitis, impetigo, rheumatic fever, and even septic shock. Group A streptococcal puerperal sepsis is uncommon today, but recent reports indicate a reemergence of virulent strains can cause toxic-mediated shock and multiple organ failure. We present a case report of a 29-year-old postpartum woman after cesarean section who presented group A streptococcal puerperal sepsis. Furthermore, we discuss the GAS strain in this patient and its relation with close contact among family members. The group A streptococci (GAS) were isolated from the patient's retroperitoneal fluid and from her husband's throat swab, respectively. Both isolates were shown to be identical: M type 1. It is well known that exotoxin A produced by M1 or M3 serotypes of the organisms plays a crucial role in streptococcal toxic shock syndrome (STSS). We conclude that in this patient, close contacts of persons with GAS appear to be at risk for colonization with identical strains of STSS-causing GAS such as M1 or M3 serotypes. Therefore, the appropriate antibiotic including antibiotic prophylaxis for close contact should be considered.

摘要

A组β溶血性链球菌可引发多种传染病,如咽炎、脓疱病、风湿热,甚至感染性休克。如今,A组链球菌产褥期败血症并不常见,但近期报告显示,毒性菌株的再度出现可导致中毒性休克和多器官功能衰竭。我们报告一例29岁剖宫产术后的产后女性发生A组链球菌产褥期败血症的病例。此外,我们讨论了该患者体内的A组链球菌菌株及其与家庭成员密切接触的关系。分别从患者的腹膜后液和其丈夫的咽拭子中分离出A组链球菌(GAS)。两种分离株显示相同:M1型。众所周知,该生物体的M1或M3血清型产生的外毒素A在链球菌中毒性休克综合征(STSS)中起关键作用。我们得出结论,在该患者中,感染GAS者的密切接触者似乎有被导致STSS的相同菌株(如M1或M3血清型)定植的风险。因此,应考虑使用适当的抗生素,包括对密切接触者进行抗生素预防。

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