Kanard Anne, Frytak Stephen, Jatoi Aminah
Department of Oncology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.
J Support Oncol. 2004 Mar-Apr;2(2):127-32; discussion 133-5, 138-40.
Cognitive dysfunction is a common occurrence among patients with small-cell lung cancer, with prevalence rates ranging anywhere from 15% to 90%. Although prophylactic cranial irradiation has been described as one culprit to explain these cognitive deficits, other causes also have been implicated. This review provides a summary of the factors that may contribute to cognitive decline in this group of patients and comments upon how cognitive dysfunction or the risk for it might influence patient management.
认知功能障碍在小细胞肺癌患者中很常见，患病率在15%至90%之间不等。尽管预防性颅脑照射被认为是导致这些认知缺陷的一个原因，但其他原因也有牵连。这篇综述总结了可能导致该组患者认知能力下降的因素，并对认知功能障碍或其风险如何影响患者管理进行了评论。
