Heth Jason
Department of Neurosurgery, University of Michigan, Taubman Medical Center, Ann Arbor, Michigan 48109, USA.
Neurosurg Focus. 2004 Aug 15;17(2):E2. doi: 10.3171/foc.2004.17.2.2.
Glomus tumors are a fascinating group of lesions. It is a challenge for neurosurgeons and otolaryngologists to resect them completely with minimal morbidity. Laboratory researchers have discovered extremely interesting genetic and molecular biology factors involved in the development and growth of glomus tumors. In this article the author reviews the genetics, protein mutations, angiogenesis and apoptosis associated with tumor formation, and the secretion of vasoactive substances is discussed as well. It is hoped that with further research less invasive measures may be developed to treat these tumors.
血管球瘤是一类引人入胜的病变。神经外科医生和耳鼻喉科医生要将其完全切除并使发病率降至最低是一项挑战。实验室研究人员已经发现了与血管球瘤的发生和生长相关的极其有趣的遗传和分子生物学因素。在本文中，作者回顾了与肿瘤形成相关的遗传学、蛋白质突变、血管生成和细胞凋亡，并且也讨论了血管活性物质的分泌。希望随着进一步研究，能够开发出侵入性更小的措施来治疗这些肿瘤。
