Esme Hidir, Ermis Sitki Samet, Fidan Fatma, Unlu Mehmet, Dilek Fatma Husniye
Department of Thoracic Surgery, Afyon Kocatepe University, Faculty of Medicine, Afyon, Turkey.
Tohoku J Exp Med. 2004 Sep;204(1):93-7. doi: 10.1620/tjem.204.93.
A 48-year-old male was admitted to our hospital because of abnormal pulmonary shadows and a decrease in visual acuity. He had a history of tuberculosis 20 years ago. The chest roentgenogram showed multiple pulmonary nodules throughout both lung fields. No definitive diagnosis was established either by brushing cytology or biopsy through bronchoscopy or percutaneous needle biopsy. Pathological examination of open lung biopsy specimen revealed that extensive, hyalinized lamellar collagen bundles arranged in whorls, parallel arrays. Plasma cells and lymphocytes were found between the collagen bands and germinal centers were seen at the periphery of the lesion. A definitive diagnosis of pulmonary hyalinizing granuloma was made on the basis of these histopathological findings. Although there is no established treatment for pulmonary hyalinizing granuloma, during 1 month of follow-up, posterior uveitis mildly resolved with glucocorticoid treatment and there had been a slight increase in visual acuity.
一名48岁男性因肺部阴影异常和视力下降入住我院。他20年前有肺结核病史。胸部X线片显示双肺野多发肺结节。通过刷检细胞学、支气管镜活检或经皮针吸活检均未明确诊断。开胸肺活检标本的病理检查显示，大量透明变性的板层胶原束呈漩涡状、平行排列。胶原带之间可见浆细胞和淋巴细胞，病变周边可见生发中心。根据这些组织病理学表现确诊为肺透明变性肉芽肿。虽然目前尚无针对肺透明变性肉芽肿的确切治疗方法，但在1个月的随访期间，后葡萄膜炎经糖皮质激素治疗后轻度缓解，视力略有提高。
