Cristoni Simone, Bernardi Luigi Rossi, Gerthoux Piermario, Gonella Elisabetta, Mocarelli Paolo
University of Milan, Centre for Bio-molecular Interdisciplinary Studies and Industrial Applications (CISI), Via Fratelli Cervi 93, 20090 Segrate Milano, Italy.
Rapid Commun Mass Spectrom. 2004;18(16):1847-55. doi: 10.1002/rcm.1558.
A new ionization method, named surface-activated chemical ionization (SACI), was employed for the analysis of five amphetamines (3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyethylamphetamine (MDE), amphetamine and methamphetamine) by ion trap mass spectrometry. The results so obtained have been compared with those achieved by using atmospheric pressure chemical ionization (APCI) and electrospray ionization (ESI) using the same instrument, clearly showing that SACI is the most sensitive of the three. The limit of detection and linearity range for SACI were compared with those obtained using APCI and ESI, showing that the new SACI approach provides the best results for both criteria. SACI was used to analyze MDA, MDMA MDE, amphetamine and methamphetamine in four urine samples, and the quantitation results are compared with those achieved using ESI.
一种名为表面活化化学电离（SACI）的新电离方法被用于通过离子阱质谱法分析五种苯丙胺类药物（3,4-亚甲基二氧基苯丙胺（MDA）、3,4-亚甲基二氧基甲基苯丙胺（MDMA）、3,4-亚甲基二氧基乙基苯丙胺（MDE）、苯丙胺和甲基苯丙胺）。将由此获得的结果与使用同一仪器通过大气压化学电离（APCI）和电喷雾电离（ESI）所取得的结果进行了比较，结果清楚地表明SACI是这三种方法中最灵敏的。将SACI的检测限和线性范围与使用APCI和ESI所获得的检测限和线性范围进行了比较，结果表明新的SACI方法在这两个标准方面都提供了最佳结果。SACI被用于分析四个尿液样本中的MDA、MDMA、MDE、苯丙胺和甲基苯丙胺，并将定量结果与使用ESI所取得的结果进行了比较。
