法国西南部粒细胞缺乏症的发病率。

Incidence of agranulocytosis in Southwest France.

作者信息

Théophile Hélène, Bégaud Bernard, Martin Karin, Laporte Juan Ramon, Capella Dolores

机构信息

Department de Pharmacologie, EA 3676, IFR 99, Université Victor Segalen, CHU Pellegrin, Bordeaux Cedex, France.

出版信息

Eur J Epidemiol. 2004;19(6):563-5. doi: 10.1023/b:ejep.0000032371.97823.85.

DOI:10.1023/b:ejep.0000032371.97823.85

PMID:15330129

Abstract

BACKGROUND

Updated knowledge of background event rates is fundamental to risk assessment.

OBJECTIVE

To estimate the incidence of agranulocytosis in the general population in Southwest France.

METHODS

All definite cases of acute non-cancer drug-related agranulocytosis in subjects aged more than 16 years were systematically retrieved weekly from Medical departments or labs in the catchment area (approximately 3.5 millions inhabitants). Event rates were compared to population figures from 1999 census data, and Poisson 95% confidence intervals computed.

RESULTS

From January 1st 1997 to December 31st 1998, 87 cases of agranulocytosis were identified, 58 being validated by an independent ad hoc panel of experts. The overall annual incidence rate was 9.2 per million inhabitants (95%CI: 6.9;13.0); 7.7 (95%CI: 4.8;11.7) per million in men, and 10.5 (95%CI: 7.2; 14.8) per million in women. These rates of all-cause acute agranulocytosis can be used as expected background reference rate for specific risk assessment.

摘要

背景

背景事件发生率的最新知识是风险评估的基础。

目的

估计法国西南部普通人群中粒细胞缺乏症的发病率。

方法

每周从集水区（约350万居民）的医疗部门或实验室系统检索所有16岁以上受试者中明确的急性非癌药物相关性粒细胞缺乏症病例。将事件发生率与1999年人口普查数据中的人口数据进行比较，并计算泊松95%置信区间。

结果

1997年1月1日至1998年12月31日，共识别出87例粒细胞缺乏症病例，其中58例经独立的特设专家小组验证。总体年发病率为每百万居民9.2例（95%置信区间：6.9；13.0）；男性为每百万7.7例（95%置信区间：4.8；11.7），女性为每百万10.5例（95%置信区间：7.2；14.8）。这些全因急性粒细胞缺乏症的发生率可作为特定风险评估的预期背景参考率。