基于血清和肿瘤组织中唾液酸化路易斯a、唾液酸化路易斯x和唾液酸化Tn抗原表达的结直肠癌患者预后差异。
Differences in prognosis of colorectal cancer patients based on the expression of sialyl Lewisa, sialyl Lewisx and sialyl Tn antigens in serum and tumor tissue.
作者信息
Akamine Shinji, Nakagoe Tohru, Sawai Terumitsu, Tsuji Takashi, Tanaka Kenji, Hidaka Shigekazu, Shibasaki Shin-Ichi, Nanashima Atsushi, Yamaguchi Hiroyuki, Nagayasu Takeshi, Yasutake Toru
机构信息
First Department of Surgery, Nagasaki University School of Medicine, Nagasaki, Japan.
出版信息
Anticancer Res. 2004 Jul-Aug;24(4):2541-6.
PURPOSE
To clarify the differences in prognosis of colorectal cancer patients based on the expression of sialyl Lewisaa sialyl Lewisx and sialyl Tn antigens in serum and tumor tissue.
PATIENTS AND METHODS
Preoperative serum levels (by radioimmunoassay) and tumor tissue expression (by immunohistochemistry) of these antigens were simultaneously determined in 52 patients. For each antigen, patients were classified into one of four groups: Group S-/T-, S-/T+, S+/T- and S+/T+. (S denotes serum, T denotes tumor tissue, and negative and positive represent expression).
RESULTS
For sialyl Lewisa antigen, the survival time of Group S+/T+ was significantly shorter than Group S-/T- or Group S-/T+ (p=0.027 or p=0.032, respectively). For sialyl Lewisx antigen, the survival time of Group S-/T+ was significantly shorter than Group S-/T- (p=0.048).
CONCLUSION
Increased expressions of sialyl Lewisa antigen in serum and sialyl Lewisx antigen in tumor tissue may be associated with poor prognosis in colorectal cancer patients.
目的
基于血清和肿瘤组织中唾液酸化路易斯a、唾液酸化路易斯x及唾液酸化Tn抗原的表达情况，阐明结直肠癌患者预后的差异。
患者与方法
对52例患者同时测定这些抗原的术前血清水平（采用放射免疫测定法）和肿瘤组织表达情况（采用免疫组织化学法）。对于每种抗原，患者被分为四组之一：S-/T-组、S-/T+组、S+/T-组和S+/T+组。（S表示血清，T表示肿瘤组织，阴性和阳性代表表达情况）。
结果
对于唾液酸化路易斯a抗原，S+/T+组的生存时间显著短于S-/T-组或S-/T+组（分别为p = 0.027或p = 0.032）。对于唾液酸化路易斯x抗原，S-/T+组的生存时间显著短于S-/T-组（p = 0.048）。
结论
血清中唾液酸化路易斯a抗原表达增加以及肿瘤组织中唾液酸化路易斯x抗原表达增加可能与结直肠癌患者的不良预后相关。
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