Raunkjaer Michael, El Oualid Farid, van der Marel Gijs A, Overkleeft Herman S, Overhand Mark
Leiden Institute of Chemistry, Leiden University, Gorlaeus Laboratories, P.O. Box 9502, 2300 RA Leiden, The Netherlands.
Org Lett. 2004 Sep 2;6(18):3167-70. doi: 10.1021/ol048750r.
[reaction: see text] Novel highly functionalized dipeptide isosters are synthesized via a diastereoselective alkyl/arylation protocol of a glucose-derived (R)-tert-butanesulfinylimine. One of these novel sugar amino acid derivatives, a D-Ala-Ser/Thr isostere, was applied in a peptide synthesis protocol to afford a cyclic tetramer.
[反应：见正文] 通过葡萄糖衍生的（R）-叔丁基亚磺酰亚胺的非对映选择性烷基/芳基化反应合成了新型高官能化二肽类似物。这些新型糖氨基酸衍生物之一，即D-Ala-Ser/Thr类似物，被应用于肽合成方案中以得到环状四聚体。
