小型综述：RET：正常与异常功能
Minireview: RET: normal and abnormal functions.
作者信息
Santoro Massimo, Melillo Rosa Marina, Carlomagno Francesca, Vecchio Giancarlo, Fusco Alfredo
机构信息
Dipartimento di Biologia e Patologia Cellulare e Molecolare, University Federico II c/o Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Naples, Italy.
出版信息
Endocrinology. 2004 Dec;145(12):5448-51. doi: 10.1210/en.2004-0922. Epub 2004 Aug 26.
The RET gene encodes a single-pass transmembrane receptor tyrosine kinase. RET is the oncogene that causes papillary thyroid carcinoma and medullary thyroid carcinoma. The latter may arise as a component of multiple endocrine neoplasia type 2 syndromes; germline mutations in RET are responsible for multiple endocrine neoplasia type 2 inheritance. In this report we review data on the mechanisms leading to RET oncogenic conversion and on RET targeting as a strategy in thyroid cancer treatment.
RET基因编码一种单次跨膜受体酪氨酸激酶。RET是导致甲状腺乳头状癌和甲状腺髓样癌的致癌基因。后者可能作为2型多发性内分泌肿瘤综合征的一部分出现；RET中的种系突变导致2型多发性内分泌肿瘤的遗传。在本报告中，我们综述了导致RET致癌转化的机制以及将靶向RET作为甲状腺癌治疗策略的数据。
Zotero 插件