Makowski Liza, Hotamisligil Gökhan S
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA, USA.
J Nutr. 2004 Sep;134(9):2464S-2468S. doi: 10.1093/jn/134.9.2464S.
Fatty acid binding proteins (FABPs) are members of a highly conserved family of proteins with the task of protecting a cell's delicate lipid balance. Yet they fail when faced with metabolic or inflammatory stress, turning the cytosol into an inhospitable environment with less than ideal outcomes. This review will focus on how FABPs direct lipid traffic and simultaneously control inflammatory and metabolic pathways under the pressures of the Metabolic Syndrome.
脂肪酸结合蛋白(FABPs)是一个高度保守的蛋白质家族成员,其任务是保护细胞脆弱的脂质平衡。然而,当面对代谢或炎症应激时,它们会失效,使细胞质变成一个不适宜生存的环境,产生不尽如人意的结果。本综述将聚焦于在代谢综合征的压力下,FABPs如何引导脂质运输并同时控制炎症和代谢途径。