Efimov Vladimir A, Chakhmakhcheva Oksana G
Institute of Bio-organic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Methods Mol Biol. 2005;288:147-64. doi: 10.1385/1-59259-823-4:147.
The methods for the synthesis and purification of negatively charged peptide nucleic acid (PNA)-relative deoxyribonucleic acid (DNA) mimics containing alternating residues of phosphono peptide nucleic acid (pPNA) monomers and PNA-like monomers on the base of trans-4-hydroxy-L-proline are described. Examples of the chimeric oligomers hybridization with complementary DNA and ribonucleic acid fragments are demonstrated.
描述了基于反式-4-羟基-L-脯氨酸合成和纯化带负电荷的肽核酸（PNA）相关脱氧核糖核酸（DNA）模拟物的方法，该模拟物含有膦酰肽核酸（pPNA）单体和PNA样单体的交替残基。展示了嵌合寡聚物与互补DNA和核糖核酸片段杂交的实例。
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