西班牙巴伦西亚15岁及以下人群百日咳发病率：儿童、青少年及成人中抗百日咳毒素（PT）抗体的血清阳性率

Incidence of pertussis in persons < or =15 years of age in Valencia, Spain: seroprevalence of antibodies to pertussis toxin (PT) in children, adolescents and adults.

作者信息

Diez-Domingo Javier, Ballester Alfredo, Baldó José-María, Planelles María-Victoria, Villarroya José V, Alvarez Trinidad, Carmen Peidró M, Calero Pura, Garcés María D, Sorribes Ignacio, Graullera Marta, Jubert Angels, San-Martín María, González Antonio

机构信息

Pediatrics, Primary Care, Generalitat Valenciana, and Vaccine Institute of Valencia (VIVA), Valencia, Spain.

出版信息

J Infect. 2004 Oct;49(3):242-7. doi: 10.1016/j.jinf.2004.03.003.

DOI:10.1016/j.jinf.2004.03.003

PMID:15337342

Abstract

PURPOSE

To determine the incidence of pertussis in persons < or =15 years in age in Valencia, Spain. To assess the prevalence of IgG antibodies to pertussis toxin (PT) in children, adolescents and adults.

METHODS

Prospective study conducted at paediatric primary care centres. All persons < or =15 years in age presented with persistent cough were enrolled. Parents completed a brief questionnaire and immunization history was obtained from paediatrician records. A blood sample was obtained, for determination of IgG antibodies to Bordetella pertussis toxin (PT) by an ELISA method. A study confirmed-case was the presence of two conditions: (1) cough illness of > or =14 days duration; and (2) ELISA absorbance value of IgG to PT > or =2. Two subjects per clinical-case (same centre and range of age) and parents were asked to participate in the prevalence study.

RESULTS

Sixty-one children < or =15 years in age presented with symptoms leading to a clinical diagnosis of pertussis were detected. Serological evidence of recent pertussis was found in five of these patients (incidence of 46.0/100,000 persons < or =15 years in age). Prevalence of antibodies to B. pertussis (> or =0.3) in children < or =15 years in age and adults was 39 and 33%, respectively. Only a minority of children, adolescents and adults had absorbance values indicative of immunity (> or =1).

CONCLUSIONS

These incidence and seroprevalence results show that despite high immunization rates in infancy, B. pertussis is circulating in Spain.

摘要

目的

确定西班牙巴伦西亚15岁及以下人群百日咳的发病率。评估儿童、青少年和成人中抗百日咳毒素（PT）IgG抗体的流行情况。

方法

在儿科初级保健中心进行前瞻性研究。纳入所有15岁及以下出现持续性咳嗽的人群。家长填写一份简短问卷，并从儿科医生记录中获取免疫史。采集血样，采用ELISA法测定抗百日咳博德特氏菌毒素（PT）的IgG抗体。确诊病例需满足两个条件：（1）咳嗽病程≥14天；（2）抗PT IgG的ELISA吸光度值≥2。每个临床病例（同一中心、相同年龄范围）选取两名受试者及其家长参与流行率研究。